The randomization is computerized and balanced by minimization for age (<or ≥40 years), gender, duration of symptoms (<or ≥1 year), and baseline Global Health Composite score of the RAND-36 Health Status Inventory (RAND SF-36), consisting of all RAND SF-36 subscales [ 22].
The grouping variables for minimization were age (younger, 50 to 62 years; older, 63 to 74 years), better hearing threshold levels (HTLs) across 0.5 to 4 kHz (better ear, 20 to 29 dB HL; poorer ear, 30 to 39 dB HL), and sex (male; female).
Centralised telephone randomization by independent statisticians was used with full allocation concealment and minimization for age, gender, baseline TICS-M score and consent for MRI.
Random allocation was performed by minimization for age, diagnosis and renal function using a computer algorithm.
(Age 21, 1 child) Minimization of side effects was one of the highest priorities when choosing a contraceptive method.
The minimization factors (age, sex, and cause of entry to ICU) must be included as covariates in the analysis for valid estimation of the intervention effect.
The randomised treatment allocation is balanced by minimization on maternal age, centre, ethnicity, and parity.
Minimization strata were age (≥ versus <40 years), diagnosis (SLE versus PSV) and baseline renal function (serum creatinine > versus ≤120 μmol/L [1.36 mg/dL]).
In this context, it is important to mention that the randomization of the study was performed with minimization for smoking status, age, previous dose of ICS, FEV1 %predicted, reversibility after 200 μg of salbutamol, PC20 methacholine, and serum IgE.
Inactivation of the proapoptotic BAX gene in mice has been shown to prolong ovarian function into advanced age (Perez et al., 2007) with minimization of many age-related health problems and, importantly, no increase in tumour incidence.
Random assignment to treatments used a minimization procedure to balance by age, sex, waist circumference, and HDL cholesterol and was completed by using a computer program.
