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Excess production of androgens or estrogens in childhood is associated with an increase in growth rate and an acceleration of epiphyseal maturation so that bone age is advanced.
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Bone age was advanced by over one year at 4.62 years using the TW2 (RUS) method [ 14] leading to a predicted final height below the cut-off of −2.5 SDS.
As oxidative damage is one of the important biomarkers of aging, we asked whether other signs of aging are advanced in per mutants.
The principal risk factor for AD is advanced age.
The greatest risk factor for Alzheimer's disease is advanced age.
Among the most significant is advanced maternal age.
This initial bonus becomes larger, depending on which age is being advanced to.
Despite the presence of multiple premature aging symptoms, not all aging processes are advanced in HGPS children.
By far the leading cause — and the one least often recognized — is advancing age.
A second important predictor of fracture is advancing age.
The strongest predictor of POAF is advancing age.
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