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Evolutionary geneticists say it most likely occurred 50,000 to 60,000 years ago, a time when the Middle East was probably a Stone Age crossroads for modern humans and Neanderthals.
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The Terminate the Rate campaign includes Age UK, Crossroads Care and Carers UK who work with the vulnerable all day, every day and know their experience.
Spears also dabbled in acting, making her big-screen debut in 2002 with the lead role in the coming-of-age film Crossroads.
These are works of law and history, science and medicine, poetry and theology, relics of Timbuktu's golden age as a crossroads in Mali for trade in gold, salt and slaves along the southern edge of the Sahara.
McCoy's birthday last May saw him reach 40 - a crossroads age for injury-prone jump jockeys.
Middle age is a crossroads, folks.
He seemed to arrive at the crossroads where age tips the benefits of experience.
It's different when an ageing athlete hits the crossroads and, as time closes in, the old intensity withers away.
Here we provide our perspective on recent findings suggesting that de novo biosynthesis of purine nucleotides, which is based on the metabolism of one-carbon compounds, is a new target for metformin's actions at the crossroads of aging and cancer.
We are at the crossroads between the Gutenberg age and the information age.
I wrote about how I had found myself at the age of 30 at a crossroads, just like Dorothy in The Wizard of Oz.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com