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Recently, several points of concern have been raised against this design, especially for matters of ethics and external validity.
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In this paper we present an unbiased discussion of the pragmatics of metamodeling tools against the background of this design rationale.
To protect against this beyond design basis accident, a second redundant set of shutdown rods is added to the reactor, so that either the usual or secondary rods can trip the reactor when there is zero coolant in the core.
This design hedges against variability.
Andy Baxter, a partner at Nicoll Russell Studios, said: "Winning this design competition against an international field is a superb accolade and we are delighted with the outcome".
To assess the feasibility of this design, antibodies against three cancer-specific biomarkers (EpCAM, HER-2, and PSA) were selected and immobilized in pattern via PAMAM dendrimers on epoxy-functionalized glass surfaces, followed by addition of E-selectin.
This design protects against several threats to validity, including history effects (external events that may affect outcomes), maturation (natural improvements over time due to experience), and testing effects (earlier measurements affecting later measurements) [ 36].
This sample selection scheme has a problem that is against the design principal of boosting, where the hardest samples should be selected for subsequent learning.
This point is addressed by comparing the measured residual map against the design residual (see Figure 5).
Moreover, this approach does not allow the possibility of automated design verification and validation against the design requirements and specifications.
Carefully place your nails against the design that you created and then submerge them slightly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com