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The phrase "against the first" is correct and usable in written English.
It can be used in contexts where you are comparing or contrasting something with a primary or initial option or choice.
Example: "In the debate, the second candidate presented stronger arguments against the first."
Alternatives: "in opposition to the first" or "contrary to the first".
Exact(53)
He voted against the first Gulf War.
Yes, Mr Kerry voted against the first Gulf war.
"This was my first time competing against the first team.
The second phase of synth-pop reacted against the first.
"I didn't like the 89-yard drive against the first team," Coughlin said.
Mr Draghi's innovations have helped the second to win the battle against the first, for now.
Similar(7)
During the drill on Thursday, the offense made a field goal against the first-team defense.
East showdown on the road against the first-place Buffalo Bills.
Jones has rarely worked against the first-team defense in practice.
Halladay will be working on three days of rest Saturday against the first-place Yankees.
Then, after 12 plays, the second-team offense went against the first-team Giants defense.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com