The phrase "against receptor" is not correct and lacks clarity in written English.
It may be intended to describe an action or effect that opposes or interacts with a receptor, but it requires additional context to be meaningful.
Example: "The drug acts against receptor activity, inhibiting its function in the body."
Alternatives: "in opposition to receptor" or "counter to receptor".
Molecular brightness and diffusion coefficient data were also plotted against receptor density (Supplementary Figs S4,S8 and S12).
The design of targeted nanocarriers against receptor clustering might provide new insight into the nanotechnology-based anticancer therapy.
Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as KDR, Flt3 and c-Kit.
Should such an upregulation of TAS2R with asthma extend to other cells/tissues including ASM, this disease feature would further favor the use of TAS2R agonists as asthma therapeutics given receptor upregulation would help protect against receptor desensitization which is believed to limit the therapeutic efficacy of anti-asthma GPCR agonists, including the beta-2-adrenoceptor27,28.
A variety of strategies for inhibiting signaling pathways have been developed, but monoclonal antibodies against receptor tyrosine kinases have been among the most successful.
The urea and thiourea derivatives played an important role in anticancer agents because of their good inhibitory activity against receptor tyrosine kinases (RTKs), protein tyrosine kinases (PTKs), and NADH oxidase which played also critical roles in many aspects of tumorigenesis [2 4].
For targeted delivery purposes, antibodies or affinity ligands against receptors of target cells or tissues may be conjugated to the surface of NPs via PEG chains [21, 22].
Interestingly, clozapine exerts higher antagonistic potencies against those receptors carrying the murine sequence 2, whereas clozapine antagonism was less potent against receptors with a corresponding human sequence.
Our study revealed lacking protection by PON2 against receptor-triggered signaling.
ERK signaling has been implicated in the proliferation, survival, and protection against receptor-mediated apoptosis of endothelial cells [ 23].
Irrespective, these results urge for further studies on the use of monoclonal antibodies against receptor-type PTPs as tumor-directed agents in glioma therapies.
