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The phrase "against disadvantages" is correct and usable in written English.
It can be used when discussing actions or strategies that counteract or mitigate negative aspects or challenges.
Example: "The new policy was implemented to work against disadvantages faced by low-income families."
Alternatives: "to counter disadvantages" or "to combat disadvantages".
Exact(1)
However, these must be weighed against disadvantages, recognised as (i) high computational demand, (ii) delineation methods can only distinguish trees in the upper canopy leading to biomass underestimation, and (iii) over- or under-segmentation of large trees can result in bias Coomes et al. (2017).
Similar(59)
But the conflict should be weighed against the disadvantages of outside prosecutors.
The report recommended that the Treasury should report on the revenue raised and weigh the new rate against its disadvantages.
Mr. Seidman at Oyster said he had been thinking about the virtues of print guidebooks, and weighing them against the disadvantages, including that many were cumbersome to carry.
People move around for work all the time – but only once they have weighed the potential benefits against the disadvantages of moving away from their friends, family, other forms of social support and, simply, familiarity.
It would be nice to draw up a tally of pluses and minuses, setting the advantage of lower input prices against the disadvantages of lower exports to the emerging world.
When selecting a valve for implantation, the advantages of each type must be weighed against its disadvantages.
Early career scientists considering a multi-investigator project should weigh the experience, networking opportunities, and prestige of a high-profile national or international collaboration against the disadvantages.
Recently, Terrier et al. [18] found that the benefits of cup medialization varies according to individual patient anatomy and stated that medialization should be balanced against possible disadvantages such as increased bone loss.
Against the disadvantages, lots of studies found that electrode/electrolyte interface degradation, gas production, and transition metal dissolution are the main factors in cycling degradation; the essence of these factors is undesired side reactions between the electrode and the electrolyte.
An example of a probabilistic exposure assessment model for chilled food application is provided and its potential added value as a food safety management tool in an industrial context is weighed against its disadvantages.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com