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The phrase "against challenges" is correct and usable in written English.
It can be used when discussing opposition or resistance to difficulties or obstacles one may face.
Example: "The team worked tirelessly against challenges to achieve their goals."
Alternatives: "in the face of challenges" or "in opposition to challenges".
Exact(57)
The political system is deeply skewed against challenges to the two incumbent parties.
He gabbles that he wants to "future proof" the NHS "against challenges ahead".
Robin understands conservatism as reactionary, a defense of elite privileges against challenges from below.
"Like every business, of course, we come up against challenges and have to work our way through them.
Mr. Romney angered many Latinos during his battle to win the Republican nomination against challenges from his right.
Mr. Herman said the real purpose of the law was to protect incumbents against challenges from candidates willing to spend their own fortunes.
Mr Bush's ineptitude allowed Europeans to become smugly indignant about the world's failure to take effective action against challenges like climate change, Islamic terrorism and global inequalities.
The court has repeatedly upheld the Voting Rights Act against challenges, and as recently as 2006 it ruled that complying with Section 5 is a compelling state interest.
That is because the only purpose of Section 5 was to offer states a "safe harbor" against challenges to their electors.
It is thus an inherently elitist and hierarchical ideology, whose essence is the defense of elite privileges against challenges from below.
Instead, the Justice Department had opted to defend DOMA against challenges like the Massachusetts case on another basis: preserving the status quo.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com