The phrase "against a large set" is correct and usable in written English.
It can be used in contexts where you are discussing comparisons, evaluations, or actions taken in relation to a significant group or collection of items, data, or individuals.
Example: "The results of the study were analyzed against a large set of variables to ensure accuracy."
Alternatives: "in comparison to a large group" or "relative to a significant dataset".
The proposed procedure is subsequently validated against a large set of advanced numerical simulations.
Then, their nonlinear capacity has been estimated using the DBELA method and their performance against a large set of ground motion records has been calculated.
The correlations were tested against a large set of experimental data gathered from the work of different investigators over the past 50 years.
The method is validated against a large set of classical two- and three-dimensional test cases covering a wide range of Reynolds numbers, in which it proves effective both in terms of accuracy and computational cost.
Since 2011, the bureau has quietly been using this system to compare new images, such as those taken from surveillance cameras, against a large set of photos to look for a match.
The model's validity was confirmed by checking the model performances against a large set of compounds not used in the development of the model [27, 28].
To understand which cell surface biological themes are differentially regulated between primary tumors and cell lines, a gene set enrichment analysis against a large sets of databases and cancer data extracted from the literature was performed.
We first used BWA [ 14] to map reads against the LT2 genome which generated a large set of possible SNP sites (Table 2).
However, because of their quadratic time complexity, rigorous dynamic programming algorithms are usually not suitable for the comparison of a large set of sequences against a database, as they demand exceptionally huge computational power and are very time consuming.
The optimized combined mechanism was validated against a larger set of experimental data over a wide range of conditions for oxidation of H2S and interactions between carbon and sulfur species.
To test this observation against a larger set of AluY insertions, we applied our locus- and SNP-selection design and analyses to the HapMap Phase II data.
