The phrase "again with a substantial" is correct and usable in written English.
It can be used when referring to a repeated action or situation that involves a significant amount or degree of something.
Example: "The team has made progress again with a substantial increase in productivity this quarter."
Alternatives: "once more with a significant" or "again with a considerable".
This year the city is adding 57 new miles of bikeways to the 127 miles already built, again with a substantial share of the funding coming from Non-Motorized Transportation programs.
And yet here he is again with a substantial, beautiful role in "Youth," playing, with unerring truthfulness, a retired composer-conductor sifting through regrets (he's had a few) as he faces the final curtain.
Following treatment with DRB we again observed a substantial increase in the pool of minichromosomes although the increase was 10 ± 6 fold less than observed in the absence of the inhibitor.
He never again wrote a substantial piece of prose fiction.
In case of update, the frameworks again introduce a substantial overhead, because they perform a read operation before an update.
Again, in a substantial minority of cases (20%, Table 4) the MRI findings were thought to be confusing or incorrect.
"I agreed a deal with Bournemouth, again it was a substantial amount of money, and then Bournemouth opened up their file and unfortunately they found they had a 50% sell-on which, unbelievably, they didn't know anything about," Fry explained.
Almost three thousand contigs in our dataset exceeded 1,000 bp in length, with the longest contig reaching nearly 14,000 bp, again a substantial improvement in comparison to most studies performed with GS20 and FLX technology.
Cluster G is a cluster with predominant specificity to ∼14, 30, 26, and 38 kDa proteins (again, a substantial difference in representation from each exposure group, where the greatest percentage was from the bitten but not infected group).
Again, we find a substantial heterogeneity: around one-third of career changers expect a wage reduction after changing.
