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The phrase "again in spite of" is correct and usable in written English.
It can be used to indicate that something is happening once more despite obstacles or challenges that would typically prevent it.
Example: "She decided to pursue her dreams again in spite of the many setbacks she faced along the way."
Alternatives: "once more despite" or "again regardless of".
Exact(17)
But again, in spite of the superficial simplicity, the attention to detail is astonishing.
My car dies again, in spite of my revs, at a roundabout.
"Groups banned once, twice, spring up again, in spite of repeated warnings," says Samina Ahmed, director of the ICG's South Asia project.So what is General Musharraf doing?
EconViews, another economics consultancy, reported a 0.4% contraction in the second quarter, writing in a report: "INDEC's indicators have grown apart from ours again, in spite of new official methodologies".
In fact, I have spent almost every August of my life on this island, in the house my parents rent over and over again in spite of its quirks: uncomfortable furniture, a first floor consumed entirely by a Ping-Pong table, a clock that stops every day at quarter to five.
Speaking at his farmhouse on a muddied hill overlooking the Pyramid stage, the Pilton farmer billed the event "a great success again, in spite of the mud and everything" – and revealed he will consider whether to continue running the world's biggest greenfield festival after its 50th anniversary year in 2020.
Similar(43)
It's more like "in spite of".
England's decision to bowl again came in spite of a knee injury suffered by the all-rounder Ben Stokes, who left the field after bowling seven overs and claiming one wicket in Sri Lanka's first innings.
What's more, the underhand motion is not nearly as wearing on the shoulder, and so the Bandits, clinging to their one-run lead in the sixth, now summoned her again, in relief, in spite of the fact that she'd pitched a complete game just twenty-four hours earlier.
Furthermore, the deadline of the project was again easily met in spite of the qualitative research approach.
The Belgian squad's tactics had worked to perfection the previous day only for Cavendish to fumble the finishing touch and over this tough loop through the Forests of Bowland and Pendle Etixx again played a blinder in spite of the fact that the hills did not suit the Manxman.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com