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Both strains also developed conditioned place preference to heroin, again in a dose-dependent manner.
Virally delivered opticin also reduced migration in all the cell lines studied, again in a dose-dependent manner.
A variety of transformed and malignant B-cell lines were also suppressed by BM-derived MSCs, again in a dose-dependent manner [ 44].
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This may also be relevant to the post-stimulus level of inflammation because of our finding that when cells are stimulated with TNFα, they are much less pro-inflammatory in the presence of wt-CFTR; the latter again acting in a dose-dependent manner suggesting that wt-CFTR suppresses not only basal inflammation but also down regulates TNFα stimulated inflammation (figure 1C).
In this treatment, we again noticed a dose-dependent change in nuclear area.
This in vivo efficacy study again demonstrated a dose-dependent reduction in the percentage of Ba/F3-JAK2V617F-GFP-positive cells after treatment at the two highest doses tested (40 and 80 mg/kg, BID × 14 days; P=8 × 10−4 and 8 × 10−7, respectively).
Similar to GM-CSF, pre-stimulation of monocytes with IFN-γ also enhanced IL-23 production in response to heat killed Salmonella, again in a dose dependent manner (Fig. 7B).
Quantitative real-time PCR was used to show that these cells also expressed no detectable endogenous CFTR and that the input of wt-CFTR cDNA once again produced a dose-dependent increase in CFTR transgene expression (figure 1E and data not shown).
The decrease was only 23% in 1C11Fk75-HT cells, again highlighting a dose-dependent effect of PrPSc.
Moreover, again a dose-dependent inhibition of SMC proliferation resulted as the concentration of DS-SILY20 increased in cultures treated with either PDGF or IFN-γ.
ML-9 induced p62 accumulation in LNCaP cells in a dose-dependent manner, once again supporting the inhibitory role for ML-9 in autophagy.
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