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After the initial recognition that the Times Square attempt was amateurish and the police and intelligence work exemplary, politicians are now suggesting that we were simply lucky and the hapless perpetrator is actually too dangerous to be handled in our criminal justice system.
However, attentive investigators in Melbourne, London, and Washington, DC soon had the virus in their laboratories (7 ) after the initial recognition of a severe epidemic, followed by the publication in The New York Times of an article in 1957 describing an epidemic in Hong Kong that involved 250,000 people in a short period (8 ).
More than 25 years after the initial recognition that HIV can directly damage the central nervous system (CNS) and lead to dementia [ 1], HIV-associated neurocognitive disorder (HAND) now encompasses a transformed spectrum of conditions due to the relative immune recovery or immune preservation facilitated by dramatic advances in antiretroviral therapy (ART).
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The ATP molecules bound before the initial recognition step are hydrolyzed before translocation.
This initial state observed kinetically has been likened to the initial recognition complexes suggested for other glycosylases.
We will return to the question concerning the initial recognition event below.
Given that setting, the declaration on July 5 that SARS had been contained (in less than 4 months after its initial recognition), represented a remarkable achievement for a truly extraordinary international public health effort.
After initial recognition of stress by cells, a signal transduction cascade is triggered through secondary messengers that transmit the signal, activating responsive genes and generating an initial response.
These results support the scenario that the bottleneck in the recognition step for IHF is spontaneous kinking of cognate DNA to adopt a partially prebent conformation and point to conformational capture as the underlying mechanism of initial recognition, with additional protein-induced bending occurring after the transition state.
The experiments show promising improvement especially for the data with low initial recognition score.
Considering that TREM-1 mRNA reached maximum levels after the initial cytokine mRNA surge and that recognition of MSU crystals via TLR signaling is believed to be among the earliest events in crystal inflammation [ 31], one may postulate that the role of TREM-1 in crystal inflammation also relates to potentiation of signals transmitted by TLRs.
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