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After the initial proliferation of group II introns within the protoeukaryotic nuclear genome, their RNA domains degenerated and evolved into spliceosomal snRNAs that functioned in trans in a common splicing apparatus (Sharp 1991; Mohr et al. 2010).
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The initial proliferation of fibroblasts on PCL/HAp films, 4 days after the seeding, was hampered compared to their proliferation on the control polystyrene surface.
Because the initial proliferation burst may not lead to establishment of a memory response, we looked for surviving OT-I CD8+ T cells in skin-draining lymph nodes 8 weeks after immunization.
γ-Irradiation after an initial proliferation phase induced by CD40 ligand and immediately prior to initiation of the differentiation phase blocked cell growth but did not affect cell viability or plasma cell differentiation.
Differentiation of TH neurons occurs gradually over time rather than in a separate burst after an initial proliferation phase.
After an initial proliferation period of 8 to 12 days, 4 cultures (id: 5, 6, 14, 16) were frozen at −80°C for 24 hours and then stored in liquid nitrogen for several weeks (up to 8 weeks).
After initial proliferation, myoblasts withdrew from the cell cycle, accumulated muscle-specific proteins, fused into multinucleated myotubes, and assembled specialized contractile structures.
Following peripheral nerve injury, NRG1 signalling is therefore dispensable for Schwann cell proliferation after the initial axonal loss and during the ensuing axonal regeneration.
The clinical and biological behavior show initial proliferation and subsequent involution [50].
Preservation of T-regulatory cells in natural hosts may reduce the levels of immune activation either by production of anti-inflammatory cytokines, such as IL-10, or by keeping T-cell proliferation at bay after the initial CD4+ T-cell loss.
This process starts a few days after the initial ischemic assault and involves activation and proliferation of endothelial cells and infiltration of myofibroblasts (Frangogiannis, 2008).
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