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We found no statistical after sumatriptan between two experimental days (P = 0.49).
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The primary end-points were changes over time in relative BOLD response after infusion of CGRP or placebo, difference in BOLD response between two experimental days, difference in BOLD response before and after sumatriptan administration and between experimental days.
Bottom middle cerebral artery (MCA) circumference changes between baseline, after infusion and after sumatriptan administration.
Y axis shows relative changes compared to baseline while the present values show relative changes between two measurements (baseline vs. infusion phase or infusion phase vs. after sumatriptan administration).
The period after sumatriptan injection was defined as the sumatriptan phase.
At 2 h, median headache score after sumatriptan was 3 and median headache score after placebo was 5. 4 h after treatment the headache score was significantly reduced after sumatriptan (p < =0.001), but not after placebo (p = 0.32) and the difference between median headache score 4 h after the two treatments (our secondary end-point) was highly significant with a p-value of 0.006.
Fig. 1 CGRP concentration before and after sumatriptan.
Headache increased 4 h after placebo (p = 0.008), but not after sumatriptan (p = 0.28) (Fig. 3).
PID at 4 h after placebo was significantly larger than after sumatriptan (p = 0.0005).
Similarly, the combination of sumatriptan and naproxen [24] resulted in more patients being sustained pain-free (24%) than after sumatriptan (16%) indicating a treatment factor for recurrence.
Some migraine patients complain of sleepiness/tiredness, difficulty in thinking and dizziness [44] after sumatriptan.
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