After the initial recognition that the Times Square attempt was amateurish and the police and intelligence work exemplary, politicians are now suggesting that we were simply lucky and the hapless perpetrator is actually too dangerous to be handled in our criminal justice system.
Given that setting, the declaration on July 5 that SARS had been contained (in less than 4 months after its initial recognition), represented a remarkable achievement for a truly extraordinary international public health effort.
However, attentive investigators in Melbourne, London, and Washington, DC soon had the virus in their laboratories (7 ) after the initial recognition of a severe epidemic, followed by the publication in The New York Times of an article in 1957 describing an epidemic in Hong Kong that involved 250,000 people in a short period (8 ).
More than 25 years after the initial recognition that HIV can directly damage the central nervous system (CNS) and lead to dementia [ 1], HIV-associated neurocognitive disorder (HAND) now encompasses a transformed spectrum of conditions due to the relative immune recovery or immune preservation facilitated by dramatic advances in antiretroviral therapy (ART).
Using this system we show that the two alternative bacterial ClpAP and ClpXP complexes share the same mechanism: after initial tag recognition, fast unfolding of substrate occurs coinciding with threading through the chaperone.
Our measurements show that R7 growth cones do not actively extend after initial target recognition.
These results support the scenario that the bottleneck in the recognition step for IHF is spontaneous kinking of cognate DNA to adopt a partially prebent conformation and point to conformational capture as the underlying mechanism of initial recognition, with additional protein-induced bending occurring after the transition state.
That highlights a big advantage for women: once they gain initial recognition, glamour can kick in.
Although further analysis may cause us to reject our initial recognition, that recognition is, when appreciative, more dependable than analysis.
The ATP molecules bound before the initial recognition step are hydrolyzed before translocation.
