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The ORR after first line palliative chemotherapy was 18%.
Still there are approximately 30% of patients who relapse after first line therapy [ 6].
The effectiveness of therapies given after first line represent patients with more established RA.
Three of this patient died of febrile neutropenia after first line carboplatin and paclitaxel combination.
However, treatment failure after first line regimens, such as spinal recurrence of disease significantly impaired outcome.
Relapse rates after first line treatment range from 5% for early stage disease to 35% for patients with advanced disease.
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Patients who progress after first-line chemotherapy are still quite healthy and desire further therapy.
There are few effective therapeutic options for patients who progressed after first-line chemotherapy.
Ramucirumab in combination with PTX was administered for one and half months after first-line chemotherapy failure.
Multiple brain infarctions were detected by magnetic resonance imaging immediately after first-line chemotherapy, which was deemed ineffective.
After first-line therapy, a complete response of the metastatic site in the lung was confirmed on chest CT.
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