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Complete remission was induced in all patients--in 19 after 2 courses of chemotherapy and in the remainder after a third course.
These data demonstrate that failure of closure of PDA after 2 courses of COI is a significant risk factor for development of CLD in ELBW infants.
*This study used the median mesothelin index, calculated by Log2 (mesothelin level after 2 courses of chemotherapy level/mesothelin level prior to chemotherapy).
Therefore, there were a total of 37 of 80 patients (46.2%) whose DA remained clinically significant after 2 courses of COI treatment.
However, despite appropriate treatments, we could not eradicate B. pertussis, and cultures were positive after 2 courses of macrolides and 1 course of cotrimoxazole given for an associated staphylococcal infection.
After 2 courses of second-line chemotherapy with gemcitabine and carboplatin, his plasma EBV DNA level fell to undetectable level which coincided with complete disappearance of metastatic lesions (i.e. complete remission) on PET-CT in October, 03.
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Eleven months later, after 22 courses of treatment, she gave Dr. Gold credit for keeping her alive and giving her extra time with her daughter, Isabel.
It almost doesn't matter what we ate, and after 38 courses, none bigger than a few bites, who can remember specifics?
Fig. 4 Abdominal CT images scan showing swollen regional lymph nodes before chemotherapy (a, b), and after 32 courses of chemotherapy (c, d).
The tumor shrank by 38% after 8 courses of chemotherapy, and we performed a laparoscopy-assisted low-anterior resection with dissection of the regional lymph nodes as planned.
After 32 courses of the combined chemotherapy, substantial shrinkage of these enlarged lymph nodes were confirmed and she underwent pylorus-preserving pancreaticoduodenectomy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com