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The phrase "afflicting downstream" is correct and usable in written English.
It can be used in contexts where something is causing harm or negative effects further along in a process or system.
Example: "The pollution from the factory is afflicting downstream ecosystems, leading to a decline in local wildlife."
Alternatives: "impacting further along" or "causing issues downstream."
Exact(1)
Furthermore, in breast cancers, it has been demonstrated that there is upregulation of the uncomplexed transcriptionally active form of β-catenin without mutations afflicting downstream components [ 53].
Similar(59)
He saw that same phenomenon afflicting Paris.
It is the fungus afflicting them.
In his criticism, he claimed that: "Traditionally, satire has comforted the afflicted while afflicting the comfortable".
"Afflicting the comfortable, blog style".
To comfort the afflicted.
He is afflicted with loneliness.
The tumours, by contrast, were fatally afflicted.
They also afflict lawmakers themselves.
A youth who afflicts Essex Fells.
Severely afflicted animals usually die.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com