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The phrase "afflicting a large proportion" is correct and usable in written English.
It can be used when discussing the impact of a problem or issue that affects a significant number of people or entities.
Example: "The disease is afflicting a large proportion of the population, leading to increased healthcare concerns."
Alternatives: "impacting a significant number" or "affecting a considerable share".
Exact(2)
"His achievements have made it possible to treat infertility, a medical condition afflicting a large proportion of humanity, including more than 10% of all couples worldwide," it said.
"His achievements have made it possible to treat infertility, a medical condition afflicting a large proportion of humanity including more than 10% of all couples worldwide," the Nobel Committee wrote, noting that approximately 4 million children have been born following IVF.
Similar(58)
Diabetes is a common chronic condition in older adults that afflicts a large proportion of the aging population as approximately 10.3 million or 20.9% of adults aged ≥ 60 years old had diabetes in 2005 [ 24] and the diabetes prevalence rates for older adults have been increasing steadily since the 1980s [ 25].
A large proportion of those afflicted with ET are completely asymptomatic at presentation.
A large proportion were still undecided.
A large proportion are mature students.
Tuckett noticed that a large proportion had literacy problems.
A large proportion of broilers suffer from leg problems.
And a large proportion are sent to people's workplaces.
Maybe a large proportion of transactions in banks are fictitious.
They also comprise a large proportion of the shelters' inhabitants.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com