Sentence examples for affinity-driven from inspiring English sources

MEDI5117 therefore represents a potential 'next-generation' antibody; future studies are planned to determine the potential for affinity-driven efficacy and/or less frequent administration.

These features together with the affinity-driven regulated release of therapeutic molecules, growth factors and gene vectors explain the rising interest for CDs as building blocks in regenerative medicine.

Here, we present the structure of the complex between the 39 kDa CnCat and a 14 residue peptide containing a PVIVIT segment that was derived from affinity-driven peptide selection based on the conserved PxIxIT motif of NFATs.

This phenomenon is referred to as affinity-driven activation (Moss DE.

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection.

Thus, GCs are necessary for the generation of high affinity AFC precursors but are not the only sites for the affinity-driven clonal selection responsible for the maturation of humoral immune responses.

As a result, knowing the HSP of every component in a membrane filtration system is the first step into developing an affinity driven model for OSN with the HSP as the main parameter to describe the internal interactions not only of the solvent but also of the solute and the membrane.

The results are consistent with a model whereby allosteric modulation of affinity drives the transition of profilin actin from the poly-Pro region to the WH2 and then to the barbed end of the filament during elongation.

Therefore, under the ELISA conditions in which the antibody concentrations are in the IC50 range of 3 4 nM, which represents ∼100 fold and ∼10 fold of Kd for hEBV321 (11.9 pM) and EBV321 (419 pM) respectively, all the antibodies exist in the bound form, thus binding in this assay is more of a stoichiometry driven event, rather then an affinity driven event.

Instead, it is tempting to speculate that in analogy to membrane-bound TNFSF ligands and cell surface anchored fusion proteins of soluble TNFSF ligands, the plasma membrane-associated spatial and mobility constraints of Fc γR-bound antibodies assist TNFRSF receptor self-affinity driven clustering of receptor2 antibody complexes.

Affinity drives the duplex formation between two oligonucleotide strands and depends on the number of mutations and the type and position of the mismatched base pair [ 23].