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Moreover, two sets of SAM-binding sites in the C-terminal regulatory domain were found recently in CBS, in which a high affinity set was responsible for kinetic stabilization of the domain and a low affinity set was involved in the enzyme activation.
These expression patterns suggest differences in transport affinity with the high affinity transport set (active under N-limitation) represented by MAE18880, 18890, 18900 and the low affinity set (active under N-replete conditions) represented by MAE14790, 14780, 14770.
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As summarized below, the new data reveal a greater than 10 fold effect of Rab6A on motor interaction with microtubules in both AMP-PNP and ADP; Rab6A prefers the AMP-PNP motor, and the motor binds Rab6A and microtubules with very similar affinity, setting up a wonderful target selection option KIF1C can pick a microtubule or a Rab6-decorated membrane.
Affinity graphs set aside questions of phylogeny in favour of capturing strong relationships among a set of input taxa.
However, considering the high affinity of SET to histones and single-stranded nucleic acids, these interactions may be important in the transcription regulatory mechanisms involved in cell determination.
The relative effect of DNA shape on nucleosome stability versus homeodomain binding affinity may set in place a fine competitive balance for binding at these sites.
In Figs. 4a and 4c, a synapse forms when BCR/Ag affinity is set to KA = 10 M−1 with A0 = 1000 antigen molecules (~100 molecules/ μm), while in Figs. 4b and 4d, where BCR/Ag affinity is set to KA = 10−5 M−1, we see that no synapse forms, as the number of BCR/Ag complexes formed is too low.
Having shown that the extended dsRBD of Dcr1 binds dsRNA with high affinity, we set out to test if RNA binding is important for import/export-promoting activity of the dsRBD of Dcr1.
These affinities were set to the same values as the affinities of KorA or KorB binding to the naked DNA strand (k3 = k1 and k4 = k2).
To improve the accuracy of binding site search, traditional methods impose filters such as phylogenetic footprinting information and transcription factor-DNA binding affinity by setting the p-value in a ChIP-chip experiment.
Her mother-in-law, who visited often, developed an affinity for the set and the set liked her-it seemed to pull away from the rest of the family and move toward her.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com