Sentence examples for affinity responsive from inspiring English sources
Several 'fishing' techniques such as BIACORE [8], drug affinity pull-down [9], drug affinity responsive target stability [10] and quantitative proteomics based affinity enrichment [11] can also assess the unexpected drug-protein interactions from a wider protein space.
Another chemical proteomic approach to target identification is DARTS (drugs affinity responsive target stability), which exploits the reduction in the protease susceptibility of the target protein on drug binding (Lomenick et al, 2009).
Through drug affinity responsive target stability (DARTS), MS and western blot analysis, we identified two redox-related proteins, Cathepsin D (CTSD) and thioredoxin-like protein 1 (TXNL1), which were significantly dysregulated following DCA treatment in LoVo cells.
To determine the underlying mechanism of DCA-induced autophagy, target identification using drug affinity responsive target stability (DARTS) coupled with ESI-Q-TOF MS/MS analysis were utilized to profile differentially expressed proteins between control and DCA-treated LoVo cells.
To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requiring chemical modification of the compound.
It contains a putative high-affinity oestrogen responsive elements mapping in proximity to transcription starting sites, suggesting NLP (KIAA0980) transcription may be directly under hormonal control.
Furthermore, we identified 220 high-affinity Estrogen Responsive Elements (EREs) distributed on the promoter regions of 163 out of the 473 up-modulated genes in ERα breast tumors.
As the GC largely consists of clonally diverse B cells, Tfh cells especially in narrow numbers are best at maintaining a selective pressure for B cell competition, favoring the survival of greater affinity antigen-responsive GC B cell clones (Pratama and Vinuesa, 2014; Victora and Mesin, 2014).
A novel thermo-responsive affinity membrane with nano-structured pores and grafted poly N-isopropylacrylamide) (poly N-isopropylacrylamideuccessfully fabricated for hydroPNIPAM adsurfacen through the membrane surface wettabilayerchange tuned by envisonmental temperature.
From our study findings, the ANs could be extendedly used for drug delivery and release, multi-layer 2D nanomaterials by the advantage of their chemical tunability, including the affinity and stimulus-responsive properties of grafting polymer as well as the geometry of scaffold structure in the ANs.
We found that Arabidopsis seedlings grown with150 μM Pi in liquid media are not able to induce the expression of AtPT2/AtPHT1 4 (PHOSPHATE TRANSPORTER 2), a high-affinity Pi transporter responsive to Pi starvation reviewed in [ 28] as revealed by analysis of Arabidopsis seedlings harboring the transcriptional AtPT2 GUS reporter.
