Sentence examples for affinity of the target from inspiring English sources

This implies that there is a relationship between the σ1 receptor binding affinity of the target compounds and the selected parameters for the study.

Owing to the higher affinity of the target that is fully complementary to the biotin-capture probe, the suboptimum label can be displaced when the complementary target is introduced into the system (see Fig.  1).

The application of novel compounds might be feasible, for example in the case of heterogeneity in the target chemokine or chemokine receptor, for example due to post-translational modifications that modify the affinity of the target for an antibody or small molecule antagonist.

In conclusion, these docked atoms help increase the binding affinity of the target-receptor molecules and optimize the hydrophobic interactions by captivating the hydrogen bonding at the hydrophobic core of the complex.

An important precondition for successful imaging was retained high affinity of the targeting agent.

These effects could be initiated by several molecular targets (predominantly receptors) that could be differentially activated by the same substance at different concentration levels and would be dependent on the affinity of the targets for the substance.

The strategy to direct the accumulation to a specific target whilst limiting nonspecific accumulation faces two problems: (1) the affinity of the targeting molecule is influenced by the large particle to which it is attached, and (2) the biodistribution of the small molecule/peptide/antibody is dominated by the large particle.

Also, as hybridization rates may differ among molecules, only the equilibrium state guarantees that actual signal intensities correlate with the concentrations and hybridization affinities of the target molecules.

This TCR was specific for HLA-A2 individuals and was of low affinity for the target.

Eventually a single MRE is identified with high specificity and affinity to the target of interest that will be useful for its detection.

The authors claimed that the selected MRE had the highest affinity for the target of interest when compared to MREs selected by other methods and suggested that multiple ultrahigh affinity MREs might exist in the enriched library [ 103].