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The structural difference between two splice isoforms markedly affects the specificity of ligand receptor binding [7], [8], [9], and exon switching is shown to be essential for development in the mouse [10], [11].
This factor mainly affects the specificity of the marker.
Limiting acetyl-CoA concentrations also affects the specificity of these proteins and also alters their order of specificity on H3 and H4.
This process is inherently prone to variability that affects the specificity and sensitivity of the assay, thus requiring evaluation of each microarray data set [ 9, 10, 12].
Therefore, further studies should address how the sum of antibodies specific for these pathogens increases the risk to trigger a particular post infectious sequel and to which extent cross-reactivity of these antibodies affects the specificity of diagnostic tests.
The individual LMWH's molecular weight affects the specificity each drug has to binding to factor II and factor Xa with smaller LWMH selectively targeting factor Xa in comparison to factor II (see Table 1).
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The conformation and lipidation status of apoE may affect the specificity of its receptor binding.
However, single-guide RNA (sgRNA) parameters affecting the specificity and efficiency of the system in flies are still not clear.
Third, false positives could be due to the cross-hybridization of paralogous gene targets to individual probes, which may affect the specificity of the SFP calling.
Moreover, markers can have limits in taxonomical assignments, mainly because of lack of consistent genome information from all possible species, affecting the specificity of the identification of the components [43].
The mechanism by which the upstream sequences affect the specificity of interaction remains unclear.
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CEO of Professional Science Editing for Scientists @ prosciediting.com