The phrase "affects the specification of" is correct and usable in written English.
You can use it when discussing how one factor influences or changes the details or requirements of something, typically in technical or formal contexts.
Example: "The new regulations affect the specification of safety standards for all manufacturing processes."
Alternatives: "influences the details of" or "modifies the requirements of".
In the present study, deletion of the BMP receptor genes, Bmpr1b and Bmpr1a, in the mouse telencephalon results in a loss of all dorsal midline cell types without affecting the specification of cortical and ventral precursors.
The failure to restrict Nodal expression to the posterior of the embryo is likely to lead to a lower threshold of Nodal signalling in this region of the embryo as the Nodal/Wnt3 amplification loop is disrupted, and this lower threshold of signalling will affect the specification of the anterior primitive streak derivatives that require the highest levels of signalling.
On this basis, we plausibly assume that the HD-induced overexpression of nodal similarly affected the specification of pigment cells in HD-expressing embryos.
Therefore, Tribolium gap genes can affect the specification of segments that are not yet formed, presumably because of interactions with the growth zone.
It remains to be clarified whether other factors affect the specification of other interneuronal subsets in a non-cell-autonomous manner.
We then investigate how different parametric assumptions for identification of the natural effects in the presence of intermediate confounders affect the specification of an extended SEM that includes nonlinearities.
Thus, loss of nf1a and nf1b does not affect the specification of OPCs at 2 dpf, but instead promotes the progressive expansion of OPCs without a concomitant increase in neuronal cell numbers.
Here we investigate: 1) how identification assumptions affect the specification of SEMs, 2) whether the more restrictive SEM assumptions can be relaxed, and 3) whether existing sensitivity analyses can be extended to this setting.
