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The phrase "affects the most" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a particular subject or group.
Example: "The new policy affects the most vulnerable members of our community."
Alternatives: "has the greatest impact" or "influences the most".
Exact(59)
TB affects the most economically-productive age, posing a significant economic burden on affected households [ 3, 16, 17].
This particularly affects the most vulnerable, including sex trafficking victims.
As a disease, trachoma mainly affects the most vulnerable members of neglected communities – women and children.
Soil erosion significantly affects the most productive lands in Argentina, particularly the region called "Pampa Ondulada".
Forced labor affects the most vulnerable and least protected people, perpetuating a vicious cycle of poverty and dependency.
A first-degree burn is the least destructive and affects the most superficial layer of skin, the epidermis.
But hardly anyone has paid attention to how this affects the most important group of all: the next generation, which is poised to inherit our poisonous baggage.
Climate action is human rights, because climate change affects the most vulnerable first and hardest – it already has, with droughts, fires, floods, crop failures.
What I think took place with the pope is that he made it clear that climate change truly affects the most vulnerable.
Senator Carl Levin, a Michigan Democrat, has tried for nearly a decade to eliminate the tax break, which affects the most commonly granted stock options.
Similar(1)
Who does this affect the most?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com