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[We've gone from a] cool startup in Silicon Valley into something that affects the mainstream" Systrom said.
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They are affecting the mainstream culture".
The regulations would not affect the mainstream matches of the World Wrestling Federation and World Championship Wrestling.
But C.I.O. was more than a name; it was a recognition that information technology was not just electronic plumbing or a narrow specialty, but something that could affect the mainstream business, strategy and competitiveness.
The creative bankruptcy that has already affected the mainstream is now trickling down to the art-house; a self-perpetuating circle of success, commission, conventionality and inevitable, dull success.
Where do you see your research affecting the mainstream?
It's amazing to see how bloggers have affected the mainstream media.
Bakula added that a number of songs from the album are already affecting the Mainstream R&B/Hip Hop and Adult R&B Building Charts.
It goes from the president to the public to the Republicans, and it doesn't affect the hard right tea party folks, but it does affect the mainstream people.
There is one overriding limitation with these "outsider" approaches, however, and that is they are playing at the margins rather than affecting the political mainstream.
Beloved by tastemakers for his work in a series of disparate indie bands — including the punky Test Icicles and the folky Lightspeed Champion — the 28-year-old musician has also affected the pop mainstream through collaborations with Solange, Kylie Minogue and Florence & the Machine.
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