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One thing always affects something else.
Affect/Effect You can only affect something that already exists.
"It may affect something long term".
Change means that something significantly new has happened.
"I think it will affect construction significantly," Mr. Fernandes said.
This has affected compliance significantly.
Hurricane Able did not affect land significantly.
Extrinsic aging factors active during these decades, will affect us significantly later.
Dose-response relationships can be affected significantly by time.
Experimental noise may affect the results significantly.
Therefore, uncertainties about them do not affect the results significantly.
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CEO of Professional Science Editing for Scientists @ prosciediting.com