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We do not believe this affects significance test results unduly.
This affects significance and is discussed in the 'discussion' section.
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Mr Blanchard and Mr Leigh ran their own battery of robustness tests, and found that excluding several different subsets of outliers including economies on IMF programmes did not affect significance.
Over-dispersion can substantially affect significance tests.
Covariate analysis did not affect significance.
Removal of protocol deviation cases from the ITT analysis did not affect significance of results.
Each of these parameters directly affects detection significance, as quantified by the signal-to-noise ratio.
No other affects approached significance.
Removing the spurious data point affects the significance observed for SpO2 during the CON trial (P > 0.05).
This discrepancy is probably due to large inter-individual variations in CYP7A1 expression which affects statistical significance.
We demonstrate how choice of pathway structure and centrality measurement, as well as the presence of key genes, affects pathway significance.
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