The phrase "affects of this mutation" is not correct in English; it should be "effects of this mutation." You can use it when discussing the consequences or impacts resulting from a specific mutation in a biological or genetic context.
Example: "Researchers are studying the effects of this mutation on the organism's overall health and development."
Alternatives: "impacts of this mutation" or "consequences of this mutation."
For example, the neuroprotective affect of the mutation in Wallerian degeneration slow (Wlds) mice has been shown to be dependent on SirT1 [13].
Thus it may not be that surprising that, of the cell types that form the filtration barrier, TRPC6 is uniquely activated in podocytes and might therefore be more sensitive to deleterious affects of mutations.
In future works we intend to apply our methodology for predicting affinity changes to protein-ligand complexes, to understand the affects of mutations that occur in drug resistance in cancer and other diseases.
Previous descriptions of families affected by this mutation had also shown overlapping phenotypes associated with a high incidence of premature sudden death, heart failure death or transplant (references in online supplementary file: 2 7,15,18, 19,21,23,27,34).
To our knowledge, this is the first report to date addressing the affect of BRCA mutations on non-cancer mortality risk.
We have not yet assessed if the interaction of SERBP1 with TDRD3 was also affected by the presence of this mutation due to antibody availability.
Because of this mutation, affected males cannot produce functional factor VIII, so that their blood fails to clot properly, leading to significant and potentially life-threatening loss of blood after even minor injuries.
The silico analysis of this missense mutation predicted a pathogenic affect; however, the biologic relevance of this mutation remains elusive [ 157, 171].
RCC affects 34% of mutation carriers, and most tumours are of chromophobe, oncocytoma, hybrid or clear cell histology.
By transferring the mutant mtDNA in transmitochondrial cytoplasmic hybrid (cybrid) cells we established the pathogenic role of this mutation, which affects CI function in homoplasmic mutant cybrids.
