Sentence examples for affects of mutations from inspiring English sources

Thus it may not be that surprising that, of the cell types that form the filtration barrier, TRPC6 is uniquely activated in podocytes and might therefore be more sensitive to deleterious affects of mutations.

In future works we intend to apply our methodology for predicting affinity changes to protein-ligand complexes, to understand the affects of mutations that occur in drug resistance in cancer and other diseases.

In addition, it has been shown that LS mutations promote the open conformation of SHP-2 (Kontaridis et al., 2006; Yu et al., 2013), which might compensate for the direct affect of mutations upon catalytic activity, resulting in a gain of function similar to NS (Yu et al., 2013).

Lastly we review the likely affects of Mendelian mutations on these multiprotein assemblies and their impacts on the form of inherited disease.

These observations are, however, subject to the caveat that the affects of these mutations might not actually be a result of their effects on O-fucosylation.

Therefore, we decided to test the affects of this mutation in HT1080 cells.

The co-inheritance of alterations in the p53 tumour suppressor pathway would therefore be expected to modify the clinical affects of a BRCA1 mutation.

To our knowledge, this is the first report to date addressing the affect of BRCA mutations on non-cancer mortality risk.

For example, the neuroprotective affect of the mutation in Wallerian degeneration slow (Wlds) mice has been shown to be dependent on SirT1 [13].

The increased number of segregating mutations by itself does not affect accumulation of mutations if recombination requires direct contact between individuals as in many animals.

RCC affects 34% of mutation carriers, and most tumours are of chromophobe, oncocytoma, hybrid or clear cell histology.