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Polypharmacology usually implies the affects mediated via the multiple targets are therapeutically "positive".
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The theoretical approach focuses on action theory for how the program affects mediating variables and on conceptual theory for how mediating variables are related to tobacco use.
To determine whether these results were specific to mastery imagery ability, this study also investigated whether another type of imagery ability (affect) mediated these relationships.
The findings for the girls were consistent with Stice's model, in that they indicated that both dietary restraint and negative affect mediated the relationship between body dissatisfaction and bulimic behavior.
The extent to which perceived size was affected mediated the perceived dominance of the actor.
Inconsistent with our hypotheses, we did not find evidence that negative affect mediated the relationship between sexual self-schemas and sexual arousal function or laboratory indices of physiological and subjective sexual arousal.
In particular, we have randomised RO-DBT participants between eight combinations of three contextual features that are not intended to be therapeutic in their own right, but may affect mediating variables, including strength of therapeutic alliance and adherence to the treatment.
There is little information on whether the level of expression of these molecules affects transduction mediated by RCAd11pGFP.
This phenomenon is explained in part by the observation that PTB1 differentially affects translation mediated by the two IRESes, despite the fact that PTB1 binds both IRESes with similar affinity.
Indeed, LTF only affects transmission mediated by receptors that contain NR2B.
To test whether AQP2 expression level affects VP/FK mediated F-actin depolymerization, we used clones in which AQP2 expression levels were different, as shown in Fig. 2.
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