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Also, without access to clinical information we were unable to verify the indication for levothyroxine treatment in cohort members that affects dosing.
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Although therapeutic indications may significantly affect dosing in older children, such variation is not generally expected in neonates.
A larger BMI may affect dosing and volume of distribution for drugs with a potential for nephrotoxicity[ 33].
A rigorous examination of how additivity to background affects dose response for different modes of action should be undertaken before its general applicability is assumed.
The increasing prevalence of imipenem resistance may also affect dosing requirements.
Pharmacogenomics identified several SNPs affecting dosing, includingCYP2C9 and VKORC1 (Higashi et al., 2002; Rieder et al., 2005; Rost et al., 2004).
In general, affected dose-specific biological processes were more frequent compared to the affected processes observed at all absorbed dose levels.
These differences might affect dose adjustment between the two subpopulations.
The factors that affect dose delivery in clinical fields (i.e., mechanical tolerances, motor fatigue, and latency effects) have been quantified.
CONCLUSIONS: Nitric oxide can be administered through 35 ft. of standard oxygen tubing without significantly affecting dose delivery.
Variables affecting dose given include patient weight, renal function, dose per unit weight and subsequent re-dosing schedule.
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