Sentence examples for affects dosage from inspiring English sources

To confirm that siRNA selectively affects dosage compensation, we asked whether reduction of Ago2 rescued females that inappropriately deploy the dosage compensation machinery, leading to toxic overexpression of both X chromosomes.

The amount of laundry and how soiled it is also affects dosage.

However, the mechanisms by which CNVs affect dosage compensation are not well understood.

Imprinting of the Drosophila Y chromosome has also been shown to partially suppress mutations affecting dosage compensation of the X chromosome in males (Menon and Meller 2009).

Elucidation of the genetic basis of many human cancers has been aided by identification of recurrent genomic DNA copy number aberrations (CNAs) affecting dosage of target genes involved in cancer pathogenesis.

The presence of Y-chromosome heterochromatin in males has been hypothesized to underlie differential sensitivity of male and female Drosophila to mutations affecting HP1 (Liu et al. 2005) and male-specific modification of heterochromatin by mutations affecting dosage compensation (Deng et al. 2009).

Genomic losses (and possibly gains) at 16p11.2 could directly contribute to the autism phenotype by affecting dosage-sensitive genes in this region, disrupting genes at the breakpoints or unmasking recessive mutations on the other allele.

Copy-number variants (CNVs) represent a significant interpretative challenge, given that each CNV typically affects the dosage of multiple genes.

In this region of the genome, CNV affects gene dosage of all genes in the block, whereas single nucleotide variation can affect the expression of just one gene.

Some pharmacologists have wondered whether race should affect prescription dosage, based on possible differences in drug metabolism.

To demonstrate that capsule splitting does not result in an equal quantity of drug in both parts of the capsule, affecting the dosage of the drug.