The phrase "affects a substantial proportion" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant number of people or things.
Example: "The new policy affects a substantial proportion of the workforce, leading to changes in job roles and responsibilities."
Alternatives: "impacts a significant number" or "influences a large segment".
CONCLUSIONS: Criminal justice involvement is a complex and costly problem that affects a substantial proportion of adults with serious mental illness who receive services across state agencies.
Gestational diabetes (GDM) affects a substantial proportion of women in pregnancy and is associated with increased risk of adverse perinatal and long term outcomes.
Poor mental health, including suicidal thoughts, affects a substantial proportion of surveyed women who are up to 2 years postpartum in the Amhara region of Ethiopia.
Please see related research by Salluh et al, http://ccforum.com/content/14/6/R210 Delirium affects a substantial proportion of hospitalized patients and increases their likelihood of unfavorable outcomes.
As partner's somatic illness is something that affects a substantial proportion of the population each year, the amounts of money spent by society on caregiver's absence from work due to caring tasks may be of considerable size in total: It has been found that caregiving reduces paid work hours for middle-aged women by 41% [ 41].
Chronic dry mouth affects a substantial proportion of the population, with reported prevalence estimates from representative samples of older people ranging from 12%to47%7% [ 1], and 10% recently reported for people in their early thirties [ 2], depending on which feature of dry mouth is being measured.
Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events.
Second, a newly released drive will typically take dozens of generations to affect a substantial proportion of a target population, unless drive-containing organisms are released in numbers constituting a substantial fraction of the population.
In conclusion, this study suggests that drug stock-outs affect a substantial proportion of patients on cART in Abidjan, even though generic the fixed-dose recommended as first-line therapy in Côte d'Ivoire, stavudine/lamivudine/nevirapine, was always in stock.
