The phrase "affects a significant proportion" is correct and usable in written English.
It can be used when discussing the impact of something on a large number of people or a substantial part of a population.
Example: "The new policy affects a significant proportion of the workforce, leading to widespread changes in job roles."
Alternatives: "impacts a large segment" or "influences a considerable share".
Type 2 diabetes affects a significant proportion of the population in North America, with an incidence directly proportional to the development of obesity (1).
Social isolation affects a significant proportion of older people and is associated with poor health outcomes.
Hypothyroidism is a common endocrine condition that affects a significant proportion of individuals worldwide.
Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population.
Poor response to ovarian stimulation affects a significant proportion of infertile couples undergoing in vitro fertilisation (IVF) treatment.
Low back pain (LBP) is a condition that affects a significant proportion of the population, with a lifetime incidence rate in excess of 70% in industrialised nations [ 1].
Pandemic, outbreak of infectious disease that occurs over a wide geographical area and that is of high prevalence, generally affecting a significant proportion of the world's population, usually over the course of several months.
Regrettably, we also have evidence that the burden from alcohol and other drugs has increased in many countries; the burden from tobacco smoking, although still affecting a significant proportion of the population, has fallen.
Peripheral diabetic neuropathy is a common and potentially disabling complication affecting a significant proportion of patients with either type 1 or type 2 diabetes [ 1].
In particular, down-regulation affected a significant proportion of genes that are key components of the pathogen-detection pathways that activate SAR and SA signalling, like FRK1.
