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The phrase "affects a significant part" is correct and usable in written English.
You can use it when discussing the impact or influence of something on a large portion of a group, system, or area.
Example: "The new policy affects a significant part of the workforce, leading to changes in job roles and responsibilities."
Alternatives: "impacts a large segment" or "influences a considerable portion".
Exact(1)
She addresses a level of awareness that seems to be diametrically opposed to that of the scientist, one that nevertheless affects a significant part of human thought and knowledge, and thus represents an essential quality of our human existence.
Similar(59)
Rich media content providers are quickly becoming key elements for mobile channel monetization affecting a significant part of the global gross domestic product.
Dental anxiety is a serious problem affecting a significant part of the population.
The level of oxygen provision affected a significant part of the transcriptome of S. cerevisiae.
In spite of a low prevalence of untreated dental caries (19.2%), dental pain, oral problems and oral impacts affected a significant part of the population studied.
Ms. Kaag raised the issue of continued high rates of malnutrition, affecting a significant part of the population, and particularly children under the age of five as well as pregnant and lactating women.
Disability affects a significant portion of the Viet Nam's population.
It's a dynamic affecting a significant portion of Detroit's small, poor population.
Hurricane Irma's wind damage will affect a significant share of Florida's small homeowners.
Just imagine if this bug had affected a significant percentage of users?
This kind of vulnerability affects a significant number of people.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com