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The phrase "affects a lot of" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a large number of people or things.
Example: "The new policy affects a lot of employees in the organization."
Alternatives: "impacts many" or "influences a large number of".
Exact(55)
It affects a lot of people".
This affects a lot of people.
Right now, we're trying to get over it because it affects a lot of people.
"It affects my personal life, my children, it affects a lot of things, it's intolerable.
This blue light affects a lot of wildlife much more than other types.
It affects a lot of people and will worry a great deal more".
Similar(5)
Big issues that affect a lot of people.
"I know it's affecting a lot of people".
Health informatics will affect a lot of people's lives.
The Rusedski outburst has affected a lot of you.
"It affected a lot of people's lives.
More suggestions(19)
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impacts a lot of
engages a lot of
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hurt a lot of
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influencing a lot of
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affects a subset of
affects a multitude of
affects a percentage of
affects a section of
affects a range of
affects a zone of
affects a bunch of
affects a part of
affects a total of
affects a sort of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com