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The phrase "affects a large number" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant quantity of people, objects, or situations.
Example: "The new policy affects a large number of employees, leading to changes in their work schedules."
Alternatives: "impacts many" or "influences a significant number".
Exact(50)
"This was a difficult decision to make since it affects a large number of dedicated employees," the president and general manager of The Times, Scott Heekin-Canedy, said in a statement.
The concept of public nuisance is closest to that of private nuisance in situations in which a public officer, acting on behalf of the community, brings suit to abate a nuisance that differs from a private nuisance only in that it affects a large number of people.
Irritable bowel syndrome (IBS) affects a large number of children throughout the world.
Osteoarthritis (OA) is a joint disease that affects a large number of the population nowadays.
Atrial fibrillation (AFib) is the most common sustained arrhythmia that affects a large number of persons.
Anorexia nervosa (AN) affects a large number of women, usually in their adolescence.
Similar(9)
Over the past decade there has been greater recognition that autism, which is a lifelong neurological condition, affects a larger number of people than was previously accepted.
Does it affect a large number of people or a small number?
If all three spike linearly, there's likely an ISP issue beyond our control affecting a large number of users.
Molly Broad, president of the American Council on Education, which represents 1,600 colleges and universities, said: "A widespread credit crisis will affect a large number of our institutions very quickly.
"I've always wanted to be a producer for a major TV network and work on stories that affect a large number of people.
More suggestions(17)
affects a vast number
affects a wide number
affects a huge number
affects a substantial number
affects a large proportion
pertains a large number
impact a large number
engages a large number
influencing a large number
affected a large number
injures a large number
impacts a large number
affecting a large number
affects a large swath
affects a limited number
affects a great number
affects a large phosphorylation
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com