Your English writing platform
Discover LudwigExact(5)
The antibiotic irreversibly inhibited chemotaxis and depressed the binding of the radiolabeled chemoattractant, fMet-Leu-[3H]Phe, to its receptor without affecting the receptor's specificity.
Side effects may be on-target (i.e. by affecting the receptor itself), off-target (i.e. via related proteins such as other kinases), or nonspecific.
But another potential explanation, given the fact that vinclozolin binds progesterone receptor in vitro, is that it is affecting the receptor directly.
When we analyzed H10-mallard and H10-JD346, we found a similar binding profile, which is consistent with the presence of similar amino acids affecting the receptor binding specificity (Table).
To avoid this issue, we sought to increase receptor expression without affecting the receptor's function.
Similar(55)
It should be noted that RTK-blocking antibodies would, in theory, only block receptors located in the cellular membrane, not affecting the receptors already internalized.
Perturbations affecting the receptor-accommodating membranes, as observed in macrophages defective for the cholesterol efflux transporters ABCA1 and ABCG1 that display an increase in free cholesterol, lead to enhanced responsiveness of TLRs, presumably as a consequence of altered plasma membrane composition (Draper et al., 2010; Yvan-Charvet et al., 2008; Zhu et al., 2008, 2010).
However, in the vicinity of a synapse, this electrical signal transforms into a chemical signal affecting the receptors of the post-synaptic neuron.
Esketamine affects the receptor for a different brain chemical called glutamate.
Binding of ligands to non-GABA sites can alter communication between different binding sites and affect the receptor's conformation in ways that stimulate or inhibit its function (allosteric modulation).
Mutation of any two sites was shown to affect the receptor's surface expression (Norskov-Lauritsen and Brauner-Osborne, 2015; Norskov-Lauritsen et al., 2015).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com