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Besides altered metabolism hypothermia might also influence cellular drug response affecting the potency of drugs.
Our investigations based on molecular docking and structure activity relationship (SAR) studies elucidated structural determinants affecting the potency at PPARα.
Dimyristoylphosphatidylserine (DMPS), phosphatidylserine from bovine brain (brain-PS), dioleoylphosphatidylserine (DOPS), and dioleoylphosphatidylglycerol (DOPG) were used to test factors affecting the potency of anionic lipid transport enhancers.
Mechanistically, this polymorphism was found to modulate the affinity of CD16 for antibodies, in turn affecting the potency of ADCC (Taylor et al, 2009).
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The deficiencies may affect the potency, purity or quality of the products, the agency said in a statement.
Prescription drugs like antibiotics, as well as foods rich in vitamin K, can affect the potency of warfarin.
One in three "non-toxic" chemicals used in the manufacture of everyday items significantly affected the potency of sperm cells, which may account for the high incidence of unexplained infertility in the human population, the researchers said.
Size variation affects the potency of the antibacterial particles.
Additionally, hydrogen bond donor substituents at C 5) significantly affected the potency and selectivity of anti-proliferation activity.
Structure activity relationship was elucidated with various substitutions on the benzene ring and these variations significantly affected the potency.
The variation in N-alkyl chain length might further affect the potency of these compounds as the substituent produces variation in the lipophilicity of the drugs [26, 28].
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