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However, each of the sites influences mRNA translation, either directly by modulating the binding affinity of PHAS-I and eIF4E or indirectly by affecting the phosphorylation of other sites.
For instance, PP1 could inhibit CaMKII function [15], [33], thereby affecting the phosphorylation on GluR1p831.
Kater et al[29] had previously reported similar findings and suggested that warfarin exerts its anti-inflammatory actions by affecting the phosphorylation of I-κB.
A screen of yeast kinase deletion mutants identified the kinase complex Pho80/85 as affecting the phosphorylation state of Adr1 serine 98 and contributing to glucose repression of some Adr1-dependent genes.
These findings suggest that the greater sensitivity of α1β2Lγ2L relative to α1β2Sγ2L toward current run-down is caused by the depletion of intracellular ATP affecting the phosphorylation status of Thr365.
CA and MF dose-dependently inhibited JNK phosphorylation and increased the phosphorylation of p38, while not affecting the phosphorylation of ERK in IL-1β-stimulated cartilage explants culture.
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In contrast, FSS13025 WT NS1 and PRVABC-59 V188A NS1 did not affect the phosphorylation of IRF3, TBK1, or IKKε (Fig. 4a d).
A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues.
We tested whether Plk1 inhibition also affects the phosphorylation of GCP-WD.
Thus, the inhibition of PP1 affects the phosphorylation of RNAPII CTD both in vitro and in cultured cells.
Changes in G-protein coupled receptors affect the phosphorylation of serine residues and subsequently a multitude of signaling pathways.
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