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Another factor affecting the inference of speciation events are species extinctions, which are assumed to be either negligible [ 63] or to have occurred at random on the phylogeny [ 19, 64].
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To study the evolution of bacteria, it is important to distinguish between vertical and non-vertical phylogenetic signals; the latter will affect the inference of phylogenetic relationships.
Defining simple corrections, we further illustrate how these effects could affect the inference of qualitative history of past populations, using the extinct Cave Bear from the Pleistocene period as an example.
As recombination brings in far more base changes to an allele than mutation which adversely affects the inference of true phylogenetic relationships, we used a population genetic approach to divide the strains into 5 groups and established the evolutionary relationships of these groups.
Rearrangement of such branches affects the inference of events only minimally and locally.
We also note that sampling design can affect the inference of σ.
The choice of normalization method is one of the primary factors that affects the inference of differential expression [ 18].
Because CpG sites are particularly prone to point mutations (64, 65), SNPs can affect the inference of DNA methylation.
We performed a power analysis to explore the possibility that cross-hybridization of non-target paralogs could affect the inference of paralogous expression profiles.
To investigate whether natural selection on the PAL may affect the inference of population structure in C. taliensis, neutrality test was performed by analyzing the entire dataset.
Missing data may interfere with the proper estimation of individual gene trees and affect the inference of the most likely species tree for that set of loci [ 119, 120].
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