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Several studies have suggested that Wnts might contribute to skin fibrosis in systemic sclerosis (SSc) by affecting the differentiation of pluripotent dermal cells.
This agent is known to negatively affect bone metabolism by means of increasing bone resorption and to inhibit bone formation by affecting the differentiation of early osteoblastic cells [ 25].
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We hypothesized that Rap1A-GTP might affect the differentiation of Treg by regulating LFA-1 activation.
In the first, further subdivided into lipomyelomeningocele and lipomyeloschisis (lipomyelocele) (Fig. 8), direct contact between the mesenchymal tissue and neural tube affects the differentiation of fatty tissue [12].
Knockdown of Rhou by shRNA in embryonic stem cells affects the differentiation of endoderm derivatives in response to Activin treatment, but not that of the mesoderm.
Environmental stresses, both external and internal may affect the differentiation of trypanosomes in the tsetse fly.
We then examined whether the loss of ß-catenin signaling affects the differentiation of the lung mesenchyme into endothelial cells.
Thus, it is reasonable to propose that ZEB1 can also affect the differentiation of the adipogenic lineage.
Similar to MOG-specific CD4+ T cells, 1,25(OH)2diddid not affect the differentiation of IFN-γ-secreting cells (Figure 3A).
Conceivably, the alteration could also affect the differentiation of stem cell precursors that contribute to a specific niche in lobuloalveolar expansion [64], [65].
To examine how changes in the expression profiles of early mesodermal markers affect the differentiation of other lineages of mesodermal origin, we analyzed the timing and quantified the levels of expression of blood, endothelial and smooth muscle cell-specific markers.
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