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Several studies have suggested that Wnts might contribute to skin fibrosis in systemic sclerosis (SSc) by affecting the differentiation of pluripotent dermal cells.
These results suggest that LPS impairs the survival of newly generated cells derived from the NSCs in the dentate gyrus without affecting the differentiation fate, and these effects of LPS were mediated presumably by COX-2 expression in the dentate gyrus.
Thus, whenever the process of reprogramming-mediated silencing fails, aberrant expression of developmental genes may occur, affecting the differentiation potential of the cells.
In the inner ear, loss of RB results in cell cycle re-entry without affecting the differentiation status of these cells (Sage et al., 2005).
This agent is known to negatively affect bone metabolism by means of increasing bone resorption and to inhibit bone formation by affecting the differentiation of early osteoblastic cells [ 25].
Furthermore, our results show that overexpression of HER-2 might cause alterations to the metabolite profiles of breast cancer independent of hormone receptor status, thus affecting the differentiation between TNBC and TPBC.
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Interestingly, neither protocol affected the differentiation process, morphological features or protein expression of mature adipocytes.
We hypothesized that Rap1A-GTP might affect the differentiation of Treg by regulating LFA-1 activation.
Thus, it was evident that filtering leads to a loss of cells and does not affect the differentiation capacities.
However, success in the development of useful applications is currently limited due to the complexity of interactions that affect the differentiation and proliferation of stem cells.
In the first, further subdivided into lipomyelomeningocele and lipomyeloschisis (lipomyelocele) (Fig. 8), direct contact between the mesenchymal tissue and neural tube affects the differentiation of fatty tissue [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com