Sentence examples for affecting the activation of from inspiring English sources

They hypothesized that weightlessness leads to decreased RhoA activity, affecting the activation of downstream Rho kinases, and impedes the phosphorylation of LIM-kinase and cofilin, thereby influencing the differentiation fate of stem cells.

Reis and coworkers ( Reis et al. 2009 ) have highlighted the importance of interfacial properties in affecting the activation of lipase molecules and this factor may be playing a major role in determining the ability of lipases to hydrolyze PHA films.

Erk inhibitor, PD98059, specifically inhibited Erk phosphorylation without affecting the activation of either JNK or p38.

Specific single point mutations within this domain alter calmodulin binding to Orai1, without affecting the activation of Orai1 channels [ 21].

Taking the data altogether, we propose a model suggesting that Wsc1p regulates mat formation by affecting the activation of the Skn7p transcription factor through the Rom2p- Rho1p module.

Other influenced kinase, WNK1 was reported to be required for EGF-dependent stimulation of ERK5 without affecting the activation of ERK1/2, JNK or p38 MAP kinases [ 36].

To functionally test the significance of E-Syt2 binding, we asked if E-Syt2 affected the activation of PAK1 by constitutively active Cdc42 or Rac in vivo.

To confirm whether HHS affected the activation of NF-κB, the DNA-binding activity of NF-κB was investigated by an EMSA.

Currently, we are beginning to understand how different types of contractile activity and mechanical loading interact and affect the activation of pathways involved in protein synthesis and degradation.

E2F1 and leucine, or insulin, together affect the activation of S6K stronger than alone suggesting that they are complementary in activating the signal pathway.

We demonstrate that multiple HDAC deletions significantly affect the activation of the Wnt-signaling pathway.