Sentence examples for affecting protein function from inspiring English sources

It requires robust and statistically reliable methods to support clinicians in the functional investigation of variants potentially affecting protein function.

Addition of 80 mM STG and 55 mM sodium citrate inhibited disulfide-mediated cross-linking without affecting protein function for each rHA tested.

VEP is good for predicting mutations affecting protein function, but additional tools to increase the prediction accuracy for rare polymorphisms were considered important.

Various studies in cell biology have demonstrated that specific RNA localization is a widely used mechanism affecting protein function at multiple levels [44].

The fact that defects in MMR proteins may alter the subcellular localization without directly affecting protein function has been largely ignored up to this point.

Cis-regulatory sequences very often control spatiotemporal expression of a gene [26] and have been suggested to play an important role during the evolution of form [21]. Mutation in cis-regulatory sequences would modify the expression profiles of Hox genes without affecting protein function [21].

The SNP substitution may affect protein function compensated by redundant functionality outside the affected protein in the larger physiological system.

These analyses are not able to identify candidate genes that have a functional variant that affects protein function, protein stability, or binding.

While most nsSNPs appear to be functionally neutral, the others affect protein function and may cause or influence diseases.

The p.A46T was predicted by the software to potentially affect protein function, whereas the p.R334H was predicted to have no functional effect.

Ng, P. C. & Henikoff, S. SIFT: predicting amino acid changes that affect protein function.