The phrase "affecting lineage" is correct and usable in written English.
It can be used in contexts discussing genetics, ancestry, or the impact of certain factors on family lines or heritage.
Example: "The study revealed several environmental factors affecting lineage and their implications for future generations."
Alternatives: "influencing ancestry" or "impacting family line".
These findings support the critical role of Oct4 in regulating stem cell identity and suggest that future experiments using RNAi in ES cells can elucidate the roles of other genes affecting lineage specification during differentiation.
Other studies show that organ-restricted NK-2 class HD TFs collaborate with ETS factors on specific target genes (Chen and Bieberich, 2005; Lin et al., 2006) or provide signal gating for decisions affecting lineage fate within developmental fields (Halfon et al., 2000; Hollenhorst et al., 2011).
The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.
Kretzschmar, K., Weber, C., Driskell, R. R., Calonje, E. & Watt, F. M. Compartmentalized epidermal activation of β-catenin differentially affects lineage reprogramming and underlies tumor heterogeneity.
We expect that better understanding of how intercellular adhesion signaling affects lineage specification may impact biomaterial and scaffold design to control stem cell fate decisions in three-dimensional context with potential implications for tissue engineering and regenerative medicine.
These approaches could produce tumorigenic insertional mutations, and residual or reactivation of transgene expression during iPSC differentiation could affect lineage choice and the functionality of iPSC derivatives [2], [9].
Despite the intense interest and investment in developing blood cell therapies from hESCs, we still lack adequate understanding of how culture conditions and differentiation protocols may affect lineage development.
It has been shown for human stem cells that cross sectional dimensions of EBs and/or the number of primarily seeded stem cells might affect lineage determination [18] and differentiation efficacy [19], we have therefore subsequently analysed the pluripotent differentiation potential of f-fEBs.
Misexpression of miRNAs in lymphocyte progenitors can affect lineage choice [ 17– 19] and effector function [ 20].
However, the molecular mechanism underlying these heterogeneities, or how they affect lineage choice is currently unknown.
DOI: http://dx.doi.org/10.7554/eLife.01067.009 Genes that affect cell fate choice can either affect lineage commitment or lineage bias.
