Sentence examples for affecting gene function from inspiring English sources

Introns may be a good source for finding DNA polymorphisms in the eukaryotic genome as they rapidly accumulate mutations without greatly affecting gene function.

In this study, to detect polymorphisms affecting gene function, we analyzed all publicly available polymorphisms in the Single Nucleotide Polymorphism Database (dbSNP) (build 125) in the exons of all 36,712 protein-coding genes that were defined in an annotation project of all human genes and transcripts (H-InvDB ver3.8)[24], [24].

To detect polymorphisms affecting gene function, we analyzed all publicly available polymorphisms in a database for single nucleotide polymorphisms (dbSNP build 125) located in the exons of 36,712 known and predicted protein-coding genes that were defined in an annotation project of all human genes and transcripts (H-InvDB ver3.8).

We propose that a careful delineation of precise deletion (or amplification) boundaries in and around these genes will be useful, since at least some of the deletions may be present simply due to the unstable nature of the chromosomal domain rather than because they contributed to the phenotype by affecting gene function.

This allowed us to introduce dsRNA in preblastoderm eggs without affecting gene function during development.

Further, there is evidence of variants in TLR or NFκB-related pathways affecting gene function.

The rs245178 and rs698172 were located in the intergenic region between CTXN3 and SLC12A2 genes, and it is still unclear whether functional elements affecting gene functions exist in this region.

Sequence variations that affect gene function and cause phenotypic variation represent functional (also known as perfect or diagnostic) markers [ 59, 60].

Given our a priori expectations of fitness impacts of SCPs, the intensity of selection against an SCP depends both on how severely the SCP allele affects gene function and how essential the affected gene is.

INDEL occurring in functionally important regions of genes could affect gene function, through gene expression modification [ 61] or RNA structure alterations [ 62].

In silico predictions, as well as discordant segregation with EVA in an affected fraternal twin pair suggest that this sequence change may not actually affect gene function or expression [22], [23].